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Injectable alginate hydrogel loaded with GDNF promotes functional recovery in a hemisection model of spinal cord injury

机译：载有GDNF的可注射藻酸盐水凝胶可促进脊髓损伤半切模型中的功能恢复

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We hypothesized that local delivery of GDNF in spinal cord lesion via an injectable alginate hydrogel gelifying in situ would support spinal cord plasticity and functional recovery. The GDNF release from the hydrogel was slowed by GDNF encapsulation in microspheres compared to non-formulated GDNF (free GDNF). When injected in a rat spinal cord hemisection model, more neurofilaments were observed in the lesion when the rats were treated with free GDNF-loaded hydrogels. More growing neurites were detected in the tissues surrounding the lesion when the animals were treated with GDNF microsphere-loaded hydrogels. Intense GFAP (astrocytes), low III tubulin (neural cells) and RECA-1 (endothelial cells) stainings were observed for non-treated lesions while GDNF-treated spinal cords presented less GFAP staining and more endothelial and nerve fiber infiltration in the lesion site. The animals treated with free GDNF-loaded hydrogel presented superior functional recovery compared with the animals treated with the GDNF microsphere-loaded hydrogels and non-treated animals.
机译：我们假设通过可注射藻酸盐水凝胶原位凝胶化在脊髓病变中局部递送GDNF将支持脊髓可塑性和功能恢复。与未配制的GDNF（游离GDNF）相比，通过将GDNF封装在微球中，从水凝胶释放的GDNF减慢了速度。当在大鼠脊髓半切模型中注射时，当用游离GDNF负载的水凝胶处理大鼠时，在病变处观察到更多的神经丝。当用载有GDNF微球的水凝胶处理动物时，在病变周围的组织中检测到更多的神经突。对于未治疗的病变，观察到强烈的GFAP（星形细胞），低III微管蛋白（神经细胞）和RECA-1（内皮细胞）染色，而经GDNF处理的脊髓表现出更少的GFAP染色以及更多的内皮和神经纤维浸润现场。与用GDNF微球负载的水凝胶和未处理的动物相比，用游离GDNF负载的水凝胶处理的动物表现出更好的功能恢复。

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